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|
Parameter
|
POI
|
DOR
|
Controlb
|
P1a
|
P2a
|
P3a
|
|---|
|
N
|
124
|
57
|
111
| | | |
|
Enrolled age, yrs, mean ± SD
|
31.3 ± 6.5
|
32.5 ± 3.8
|
48.0 ± 6.1
|
< 0.001
|
< 0.001
|
0.149
|
|
Age at menarche, yrs, mean ± SD
|
13.4 ± 1.6
|
13.2 ± 1.2
| | | |
0.395
|
|
Age at menopause, yrs, mean ± SD
|
28.4 ± 7.1
|
NA
|
50.7 ± 3.0
|
< 0.001
| | |
|
BMI (kg/m2), mean ± SD
|
22.1 ± 3.8
|
21.6 ± 3.5
|
25.0 ± 3.2
|
< 0.001
|
< 0.001
|
0.351
|
|
Currently Smoking, No. (%)
|
3 (2.7)
|
1 (1.8)
|
2 (1.8)
|
0.307
|
0.565
|
0.593
|
|
FSH (IU/l), mean ± SD
|
81.7 ± 35.8
|
15.0 ± 4.8
|
30.5 ± 30.8
|
< 0.001
|
< 0.001
|
< 0.001
|
|
Estradiol (pg/ml), mean ± SD
|
33.3 ± 38.4
|
46.4 ± 27.6
|
87.7 ± 125.1
|
< 0.001
|
0.001
|
0.027
|
|
AMH (ng/ml), mean ± SD
|
0.06 ± 0.18
|
0.80 ± 0.76
| | | |
< 0.001
|
|
FMR1 Allele1, mean ± SD
|
29.8 ± 2.1
|
29.3 ± 3.5
|
29.9 ± 3.8
|
0.694
|
0.281
|
0.330
|
|
Median [IQR]
|
29 [29,30]
|
30 [29,31]
|
30 [29,31]
| | | |
|
FMR1 Allele2, mean ± SD
|
33.4 ± 7.7
|
32.2 ± 4.1
|
33.2 ± 5.0
|
0.847
|
0.202
|
0.290
|
|
Median [IQR]
|
30 [30,36]
|
31 [30, 34.5]
|
31 [30,37]
| | | |
- aP1 indicated POI versus controls, P2 indicated DOR versus controls, and P3 indicated POI versus DOR
- b the characteristics presented in the Table were results at baseline assessment of the women in the control group
- Abbreviation: POI Premature ovarian insufficiency, DOR Diminished ovarian reserve, FSH Follicle-stimulating hormone, AMH Anti-mullerian hormone, SD Standard deviation, BMI Body mass index, IQR Interquartile range, NA Not applicable
