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FMR1 CGG Repeats
|
N
|
<25
|
25–29
|
30–34
|
35–39
|
40–44
|
45–54 (Intermediate)
|
55–199 (Premutation)
|
|---|
|
Allele1
|
|
POI group, N (%)
|
124
|
2 (1.6)
|
65 (52.4)
|
52 (41.9)
|
4 (3.2)
|
1 (0.8)
|
0
|
0
|
|
Age at menopause, yrs., mean (SD)
| |
16.5 (2.1)
|
28.9 (7.3)
|
28.7 (6.5)
|
23.5 (6)
|
22
| | |
|
FSH (IU/l), mean (SD)
| |
95.2 (43.3)
|
79 (36.2)
|
81.4 (38.5)
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67.5 (34.9)
|
129.3
| | |
|
AMH (ng/ml), mean (SD)
| |
0
|
0.1 (0.3)
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0 (0.1)
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0
|
0
| | |
|
DOR group, N (%)
|
57
|
5 (8.8)
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22 (38.6)
|
29 (50.9)
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1 (1.8)
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0
|
0
|
0
|
|
FSH (IU/l), mean (SD)
| |
17.8 (8.8)
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15.5 (4.7)
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14.1 (3.9)
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16.9
| | | |
|
AMH (ng/ml), mean (SD)
| |
1.0 (0.9)
|
0.7 (0.6)
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0.8 (0.8)
|
0.9
| | | |
|
Control group, N (%)
|
111
|
9 (8.1)
|
24 (21.6)
|
72 (64.9)
|
5 (4.5)
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1 (0.9)
|
0
|
0
|
|
Age at menopause, yrs., mean (SD)
| |
52 (2)
|
50.5 (3.3)
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50.5 (2.9)
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52.8 (4)
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51.0
| | |
|
FSH (IU/l), mean (SD)
| |
27.3 (29.5)
|
26.9 (26.9)
|
32.5 (32.7)
|
21.8 (29.6)
|
52.9
| | |
|
Allele2
|
|
POI group, N (%)
|
124
|
0
|
29 (23.4)
|
56 (45.2)
|
27 (21.8)
|
9 (7.3)
|
1 (0.8)
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2 (1.6)
|
|
Age at menopause, yrs., mean (SD)
| | |
29.6 (6.7)
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27.9 (7.4)
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27.6 (7.5)
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27.8 (5.5)
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30.0
|
35.5 (2.1)
|
|
FSH (IU/l), mean (SD)
| | |
87.2 (36.8)
|
80.8 (39.5)
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76.5 (36.2)
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70.2 (29.6)
|
110.5
|
59.1 (10.3)
|
|
AMH (ng/ml), mean (SD)
| | |
0.0
|
0.1 (0.3)
|
0.0
|
0.0
|
0.0
|
0.1 (0.2)
|
|
DOR group, N (%)
|
57
|
0
|
13 (22.8)
|
30 (52.6)
|
10 (17.5)
|
3 (5.3)
|
1 (1.8)
|
0
|
|
FSH (IU/l), mean (SD)
| | |
15.9 (4.7)
|
14.4 (5.3)
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15.3 (3.8)
|
17.4 (1.5)
|
11.0
| |
|
AMH (ng/ml), mean (SD)
| | |
0.5 (0.6)
|
0.9 (0.9)
|
0.9 (0.6)
|
0.4 (0.3)
|
0.7
| |
|
Control group, N (%)
|
111
|
0
|
22 (19.8)
|
54 (48.6)
|
26 (23.4)
|
6 (5.4)
|
2 (1.8)
|
1 (0.9)
|
|
Age at menopause, yrs., mean (SD)
| | |
51.3 (3)
|
50.5 (3.1)
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50.9 (3)
|
51 (1.9)
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46.5 (2.1)
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51.0
|
|
FSH (IU/l), mean (SD)
| | |
23.6 (25.3)
|
28.8 (30.7)
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39.3 (34.5)
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15.2 (18.8)
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68.9 (32.3)
|
52.9
|
- Fisher’s exact tests for allele 1: comparison by POI versus control (P < 0.001); comparison by DOR versus control (P = 0.148). Fisher’s exact tests for allele 2: comparison by POI versus control (P = 0.903); comparison by DOR versus control (P = 0.884). The menopausal ages, values of FSH and AMH of women with different CGG repeats groups showed no statistically significant difference (P > 0.05)
- Abbreviation: POI Primary ovarian insufficiency, DOR Diminished ovarian reserve, FSH Follicle-stimulating hormone, AMH Anti-mullerian hormone
