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Outcomes
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OHSS group (n = 385)
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Binary logistic regression analysis Propensity score matching
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Unmatched (n = 6356)
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P value
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Matched 1:4 (n = 1540)
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P value
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Live birth delivery rate, no. (%)
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338/385 (87.8)
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5380/6356 (84.6)
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0.164
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1331/1540 (86.4)
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0.481
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Singleton, no. (%)
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174/338 (51.5)
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3913/5380 (72.7)
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< 0.001
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721/1331 (54.2)
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0.376
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Multiple, no. (%)
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164/338 (48.5)
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1467/5380 (27.3)
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< 0.001
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610/1331 (45.8)
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0.376
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Preterm delivery, no. (%)
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67/338 (19.8)
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1456/5380 (27.1)
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< 0.001
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262/1331 (19.7)
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0.955
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Miscarriages, no. (%)
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47/385 (12.2)
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976/6356 (15.4)
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0.164
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209/1540 (13.6)
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0.481
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Early miscarriages, no. (%)
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23/385 (6.0)
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607/6356 (9.6)
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0.160
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137/1540 (8.9)
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0.063
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Obstetric complications, no. (%)
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27/385 (7.0)
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414/6356 (6.5)
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0.700
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49/1540 (3.2)
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0.001
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PP, no. (%)
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3/385 (0.8)
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35/6356 (0.6)
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0.404
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5/1540 (0.3)
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0.215
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GDM, no. (%)
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7/385 (1.8)
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82/6356 (1.3)
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0.178
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9/1540 (0.6)
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0.017
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HDP, no. (%)
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12/385 (3.1)
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137/6356 (2.2)
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0.117
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34/1540 (2.2)
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0.184
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ICP, no. (%)
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2/385 (0.5)
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7/6356 (0.1)
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0.056
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1/1540 (0.1)
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0.104
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VT, no. (%)
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2/385 (0.5)
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0
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< 0.001
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0
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0.040
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Duration of gestation (weeks) (mean + SD)
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38.0 ± 2.2
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38.7 ± 2.0
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0.020
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38.7 ± 2.1
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< 0.001
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Neonatal births
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503
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6855
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1946
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Neonatal complications, no. (%)
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18/503 (3.6)
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193/6855 (2.8)
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0.322
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40/1946 (2.1)
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0.045
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NICU, no. (%)
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16/503 (3.2)
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143/6855 (2.1)
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0.103
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33/1946 (1.7)
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0.034
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Congenital diseases, no. (%)
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2/503 (0.4)
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15/6855 (0.2)
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0.420
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1/1946 (0.1)
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0.048
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Average neonatal weight (g) (mean + SD)
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2800.7 ± 588.6
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3040.0 ± 655.3
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< 0.001
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2853.6 ± 659.6
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0.081
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LBW, no. (%)
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128/503 (25.5)
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1228/6855 (17.9)
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< 0.001
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528/1946 (27.1)
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0.441
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- Note: Data are n (%) unless otherwise indicated. Plus-minus values are the mean±SD; SD Standard deviation. Statistically significant (P<0.05). OR, Odds ratio
- Live birth delivery rate; the number of deliveries that resulted in at least one live birth, expressed per 100 cycle attempts. the denominator in our study is the number of pregnancies who were diagnosed with clinical pregnancy after IVF/ICSI- fresh ET
- Premature delivery was defined as birth before 37 completed weeks and after 28 completed weeks of pregnancy
- Miscarriage included early- and late-term miscarriages. Early miscarriages occurred before 12 gestational weeks, and late-term miscarriages occurred between 13 and 28 gestational weeks
- Obstetric complications; PP Placenta previa, GDM Gestational diabetes mellitus, PROM Premature rupture of the fetal membranes, HDP hypertensive disorder of pregnancy, including gestational hypertension, preeclampsia, and eclampsia, ICP Intrahepatic cholestasis of pregnancy, VT Venous thrombosis
- Neonatal complications included prematurity, extremely low birth weight, perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs
- NICU, neonatal intensive care unit, which concentrates on the care of premature babies and sick newborns, due to extreme low birth weight (LBW), perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs and other complications
- Other neonatal complications: One neonatal death occurred in the NICU, and two congenital diseases occurred in the OHSS group. In the matched non-OHSS group, one death occurred within one year after birth, and one congenital disease, one chromosomal abnormality and five congenital diseases were present
- LBW Low birth weight (birth weight <2500 g)
- Threatened abortion refers to a small amount of vaginal bleeding, often dark red or bloody leukorrhea and accompanying paroxysmal abdominal pain or lower back pain in the absence of pregnancy discharge at <28 weeks of pregnancy
