Table 2 Studies evaluating altered lncRNA expression in women with and without PCOS
From: Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis
| Study | Detected in tissue/cell | No. of PCOS and control | Age of PCOS/ control (years) | BMI of PCOS/ control (m/kg2) | Dysregulated lncRNAs |
|---|---|---|---|---|---|
| Liu et al. 2015 [79] | Peripheral blood leukocytes | 23 PCOS vs 17 controls | 28.44 ± 0.37/29.71 ± 0.44 | 28.88±0.37/27.01 ± 1.1 | Upregulated: lncRNA CTBP1-AS |
| Liu et al. 2015 [80] | Peripheral blood leukocytes | 23 PCOS vs 17 controls | 28.44 ± 0.37/29.71 ± 0.44 | 27.74 ± 1.56/26.61 ± 1.10 | Upregulated: lncRNA SRA |
| Huang et al. 2016 [81] | Cumulus cells | 35 PCOS vs 35 controls | 32.6 ± 3.1/ 34.6 ± 2.2 | 21.6 ± 1.5/ 21.4 ± 1.8 |
620 upregulated and 3 downregulated The most upregulated: lncRNA ENST00000433673, The most downregulated: lncRNA NR_027436 |
| Liu et al. 2017 [82] | Granulosa cells | 7 PCOS vs 7 controls | 29.71 ± 3.59/30.14 ± 2.97 | 20.8 ± 1.96/ 22.34 ± 1.12 |
692 upregulated and 170 downregulated The most upregulated: lncRNA ENST00000533082, The most downregulated: lncRNA ENST00000448179 |
| Huang et al. 2018 [83] | Cumulus cells | 30 PCOS vs 30 controls | 32.6 ± 3.1/ 33.6 ± 2.2 | 21.6 ± 1.5/ 21.4 ± 1.6 | Upregulated: lncRNA PWRN2 |
| Jiao et al. 2018 [84] | Follicular fluid | 10 PCOS vs 8 controls | 30.6 ± 3.86/ 30.0 ± 4.21 | 25.9 ± 3.14/ 24.7 ± 3.69 | A total of 1583 novel lncRNAs were identified |
| Lin et al. 2018 [85] | Serum | 16 PCOS without IR vs 30 PCOS with IR vs 30 healthy controls | 28.3 ± 3.1/ 31.3 ± 4.6/ 26.8 ± 6.7 | 20.9 ± 3.6/ 25.1 ± 3.5/19.5 ± 2.4 | Downregulated in PCOS patients with IR: lncRNA GAS5 |
| Zhao et al. 2018 [86] | Luteinized granulosa cells | 30 PCOS vs 30 controls | 28 ± 3/ 29 ± 3 | 23.3 ± 2.9/ 21.8 ± 2.4 |
Upregulated: LINC-01572:28 |
| Yang et al. 2019 [87] | Granulosa cells | 44 PCOS vs 34 controls | 31.2 ± 3.4/ 30.9 ± 3.1 | NA/ NA | Upregulated: lncRNA BANCR |
| Li et al. 2019 [88] | Peripheral blood leukocytes | 20 PCOS vs 20 controls | 28.45 ± 1.35/ 31.7 ± 1.52 | 25.21 ± 0.86/ 20.56 ± 0.58 | Upregulated: lncRNA H19 |