Table 3 Studies evaluating altered circRNA expression in women with and without PCOS
From: Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis
| Study | Detected in tissue/cell | No. of PCOS and control | Age of PCOS/ control (years) | BMI of PCOS/ control (m/kg2) | Dysregulated circRNAs |
|---|---|---|---|---|---|
| Che et al. 2019 [95] | Cumulus cells | 20 PCOS vs 20 controls | 30.4 ± 2.5/29.8 ± 3.1 | 22.3 ± 1.4/21.8 ± 1.5 | Downregulated: circRNA-0083952, 0082709, 0002425, and 0015168 |
| Ma et al. 2019 [96] | Cumulus cells | 25 PCOS vs 25 controls | 29.60 ± 2.76/ 31.16 ± 3.28 | 24.46 ± 2.47/ 21.16 ± 2.04 |
Upregulated: circRNA-0043533 and 0043532 Downregulated: circRNA-0097636 |
| Wang et al. 2019 [97] | Exosomes of follicle fluids | 3 PCOS vs 3 controls | 24, 25, 27/ 26, 27, 28 | 22.4, 26.4, 20.3/22.9, 16, 22.3 |
167 upregulated and 245 downregulated The top five most upregulated: circRNA-15918_GREB1L,2702_ANKH, 7788_HTT, 5762_SPHKAP, and 8717_FANCL The top five most downregulated: circRNA-5172_NBPF20, 14485_MBOAT2, 15481_ATP6V0D1, 6172_LINC-PINT, and 6485 _LYRM4 |
| Zhang et al. 2019 [98] | Granulosa cells | 15 PCOS vs 15 controls | 29.20 ± 2.42/ 29.73 ± 3.39 | 20.82 ± 1.68/ 19.84 ± 1.00 |
Upregulated: circRNA-0001577 Downregulated: circRNA-0020093 |