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Table 5 List of ncRNAs observed in PCOS

From: Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis

ncRNAs Detected in cell/tissue Expression Target gene(s)/acting pathway Reported function(s) References  
miR-93 Adipose tissue ↑ GLUT4 Correlated with insulin resistance [26]  
Granulose cells ↑ CDKN1A Promotes proliferation and cell cycle progression [27]  
Granulose cells ↑ SMAD7 and TGFBR2 Impaired follicle development [49]  
Plasma ↑ NGF Signalling and HGF Signalling Correlated with insulin resistance [32]
miR-320 Serum ↓ Through ET-1 regulating ERK1/2 signalling pathway Promotes cell mitosis [44]
Cumulus cells ↓ RUNX2 Estrogen deficiency [58]  
Ovarian tissue ↓ Through IRS-1 regulating ERK1/2 signalling pathway Inhibits insulin resistance [72]  
Follicular fluid ↓ RAB5B Correlated with insulin resistance [25]  
Follicular fluid, granulosa cells ↑ E2F1 and SF-1 Inhibited estradiol release and cell proliferation; enhanced progesterone synthesis [46]  
miR-9 Follicular fluid ↑ IRS2, SYT1, IL8 Mediates the effects of insulin; steroid synthesis [45]  
miR-18b Follicular fluid ↑ IRS2, SYT1, IL8 Mediates the effects of insulin; steroid synthesis [45]  
miR-135a Follicular fluid ↑ IRS2, SYT1, IL8 Mediates the effects of insulin; steroid synthesis [45]  
  Granulosa cells ↑ ESR2 Promoted proliferation and inhibited apoptosis [67]  
miR-186 Granulosa cells ↑ ESR2 Promoted proliferation and inhibited apoptosis [67]  
miR-21 Serum ↑ LATS1 Promotes secondary follicle growth [31]
Granulose cells ↑ SMAD7 and TGFBR2 Impaired follicle development [49]  
miR-592 Serum ↓ LHCGR Inhibited cell viability and cell cycle progression [33]  
miR-92a Ovarian theca interna tissues ↓ GATA-6 and IRS-2 Related to androgenic and insulin signaling pathways [17]  
miR-223 Plasma ↑ PPAR, IGF-1 and angiopoietin signaling Correlated with insulin resistance hyperandrogenism, endometrial response and ovarian follicle development [32]
miR-483 Ovary cortex ↓ IGF1 Inhibits cell proliferation [71]  
miR-483-5p Cumulus granulosa cells ↓ Notch3 and MAPK3 Related to cell proliferation and apoptosis [55]  
Cumulus cells ↓ IGF2 Inhibits insulin resistance [53]  
miR-486-5p Cumulus cells ↓ PI3K/Akt Promote cumulus cell proliferation [53]  
miR-509-3p Cumulus cells ↑ MAP3K8 Improved oestradiol secretion [56]  
miR-6767-5p Serum ↓   Negatively associated with fasting glucose [36]  
miR-145 Granulosa cells ↓ IRS1 Negatively Regulates Cell Proliferation [57]  
miR-126-5p Granulosa cells ↓ Klotho-associated signaling Involved in apoptosis of cells [60]  
miR-29a-5p Granulosa cells ↓ Klotho-associated signaling Involved in apoptosis of cells [60]  
miR-27a-3p Granulosa cells ↑ SMAD5 Decreased cell proliferation and promoted cell apoptosis [61]  
miR-335-5p Follicular fluid ↓ SGK3 Involved in granulosa cells proliferation [51]  
miR-873-5p Follicular fluid ↑ Heme oxygenase-1 (HO-1) Involved in apoptosis of cells [52]
miR-19b Granulosa cells ↓ IGF-1 Promotes cell proliferation [62]  
miR-99a Granulosa cells ↑ IGF-1 Regulates proliferation and apoptosis [63]
miR-33b Granulosa cells ↑ TGFBR1 Induced dysregulated cell proliferation, apoptosis, and cell cycle [64]  
miR-142 Granulosa cells ↑ TGFBR1 Induced dysregulated cell proliferation, apoptosis, and cell cycle [64]  
miR-423 Granulosa cells ↓ SMAD7 Induced dysregulated cell proliferation, apoptosis, and cell cycle [64]  
miR-23a Granulosa cells ↑ SIRT1 Promotes cell apoptosis [65]  
miR-130b-3p Ovarian theca cells ↑ DENND1A Variant 2 Correlated with androgen biosynthesis [73]
lncRNA CTBP1-AS Peripheral blood leukocytes ↑   Reguletes androgen receptor AR activity [79]
lncRNA SRA Peripheral blood leukocytes ↑   Promote activity of steroid receptors [80]
lncRNA PWRN2 Cumulus cells ↑ miR-92b-3p and TMEM120B Correlated with oocyte nuclear maturation [83]
lncRNA GAS5 Serum ↓   Correlated with insulin resistance,cell apoptosis and proliferation [85]
lncRNA BANCR Granulosa cells ↑ Bax and p53 promote apoptosis [87]
lncRNA LINC-01572:28 Luteinized granulosa cells ↑ SKP2 and p27 inhibits cell proliferation and cell cycle [86]
lncRNA H19 Peripheral blood leukocytes ↑   correlated with fasting plasma glucose levels [88]
  1. Abbreviations: TGFBR1 transforming growth factor beta receptor 1, NGF nerve growth factor, HGF hepatic growth factor, ET-1 endothelin-1, IRS1 insulin receptor substrate 1, IRS insulin receptor substrate, SYT1 synaptogamin 1, IL8 interleukin 8, LATS1 large tumor suppressor, LHCGR luteinizing hormone/chorionic gonadotropin receptor, GATA6 GATA-binding factor 6, IRS-2 insulin receptor substrate proteins 2, PPAR peroxisome proliferator receptor, IGF-1 insulin like growth factor-1, SGK3 serum/glucocorticoid-regulated kinase family member 3, ↑ the expression of ncRNAs was upregulated, ↓ the expression of ncRNAs was downregulated
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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