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  1. This study compared the effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa; GONAL-f®) with urinary highly purified human menopausal gonadotropin (hMG HP; Menogon HP®), during assist...

    Authors: Klaus F. Bühler, Robert Fischer, Patrice Verpillat, Arthur Allignol, Sandra Guedes, Emmanuelle Boutmy, Wilma Bilger, Emilia Richter and Thomas D’Hooghe

    Citation: Reproductive Biology and Endocrinology 2021 19:90

    Content type: Research

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  4. After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3.3 is a histone H3 variant th...

    Authors: Shi-meng Guo, Xing-ping Liu and Li-quan Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:87

    Content type: Short communication

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  5. Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to...

    Authors: Yixin Wang, Jing Xiu, Tingting Yang, Chune Ren and Zhenhai Yu

    Citation: Reproductive Biology and Endocrinology 2021 19:86

    Content type: Research

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  6. The importance of spermatogonial stem cells (SSCs) in spermatogenesis is crucial and intrinsic factors and extrinsic signals mediate fate decisions of SSCs. Among endogenous regulators, microRNAs (miRNAs) play...

    Authors: Maryam Khanehzad, Seyed Mehdi Nourashrafeddin, Farid Abolhassani, Shokoofeh Kazemzadeh, Soheila Madadi, Elham Shiri, Parastoo Khanlari, Zahra Khosravizadeh and Azim Hedayatpour

    Citation: Reproductive Biology and Endocrinology 2021 19:85

    Content type: Research

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  7. Uterine adenomyosis is a benign disease, common among women in their 40 and 50 s, characterised by ectopic endometrial tissue in the uterine myometrial layer. Adenomyosis causes infertility and has a negative ...

    Authors: Takuya Iwasawa, Toshifumi Takahashi, Eri Maeda, Koichi Ishiyama, Satoshi Takahashi, Ryota Suganuma, Koki Matsuo, Masahito Tachibana, Rie Fukuhara, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa and Yukihiro Terada

    Citation: Reproductive Biology and Endocrinology 2021 19:84

    Content type: Research

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  8. Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.

    Authors: Qigui Xie, Yaxin Xing, Jianhong Zhou, Ling Wang, Jie Wu and Ri-Cheng Chian

    Citation: Reproductive Biology and Endocrinology 2021 19:83

    Content type: Research

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  9. Recent studies have revealed that women with infertility have a higher risk of thyroid cancer (TC) than fertile women. However, studies on whether a history of thyroid cancer affects clinical outcomes in women...

    Authors: Ning Huang, Lin Zeng, Jie Yan, Hongbin Chi and Jie Qiao

    Citation: Reproductive Biology and Endocrinology 2021 19:82

    Content type: Research

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  10. Let-7a is a small non-coding RNA that has been found to take part in cell proliferation and apoptosis. The hippo-YAP1 axis, known as a tumour suppressor pathway, also plays an important role in cell proliferat...

    Authors: Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang and Cheng-Xiao LV

    Citation: Reproductive Biology and Endocrinology 2021 19:81

    Content type: Research

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  11. Ovarian reserve reflects the quality and quantity of available oocytes and has become an indispensable measure for the better understanding of reproductive potential. Proteomic approaches are especially helpfu...

    Authors: Sanglin Li, Lina Hu and Chanyu Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:80

    Content type: Research

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  12. The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality.

    Authors: Ammar Al Naimi, Pablo Moore, Dörthe Brüggmann, Lisa Krysa, Frank Louwen and Franz Bahlmann

    Citation: Reproductive Biology and Endocrinology 2021 19:79

    Content type: Research

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  13. Traditionally, final follicular maturation is triggered by a single bolus of human chorionic gonadotropin (hCG). This acts as a surrogate to the naturally occurring luteinizing hormone (LH) surge to induce lut...

    Authors: Kai-Lun Hu, Siwen Wang, Xiaohang Ye, Dan Zhang and Sarah Hunt

    Citation: Reproductive Biology and Endocrinology 2021 19:78

    Content type: Review

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  14. Polycystic ovary syndrome (PCOS) causes anovulation and is associated with a reduced clinical pregnancy rate. Metformin, which is widely used for treating PCOS, can lead to successful pregnancy by restoring th...

    Authors: Miki Ohara, Hiromi Yoshida-Komiya, Miho Ono-Okutsu, Akiko Yamaguchi-Ito, Toshifumi Takahashi and Keiya Fujimori

    Citation: Reproductive Biology and Endocrinology 2021 19:77

    Content type: Research

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  15. The majority of available studies on the AMH thresholds were not age-specific and performed the receiver operating characteristic curve (ROC) analysis, based on variations in sensitivity and specificity rather...

    Authors: Fahimeh Ramezani Tehrani, Maryam Rahmati, Fatemeh Mahboobifard, Faezeh Firouzi, Nazanin Hashemi and Fereidoun Azizi

    Citation: Reproductive Biology and Endocrinology 2021 19:76

    Content type: Research

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  16. Increasing evidence supports a relationship between obesity and either infertility or subfertility in women. Most previous omics studies were focused on determining if the serum and follicular fluid expression...

    Authors: Chenchen Si, Nan Wang, Mingjie Wang, Yue Liu, Zhihong Niu and Zhide Ding

    Citation: Reproductive Biology and Endocrinology 2021 19:75

    Content type: Research

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  17. Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder with various manifestations and complex etiology. Follicular fluid (FF) serves as the complex microenvironment for follicular development...

    Authors: Li Yu, Miao Liu, Zhenxin Wang, Te Liu, Suying Liu, Beili Wang, Baishen Pan, Xi Dong and Wei Guo

    Citation: Reproductive Biology and Endocrinology 2021 19:74

    Content type: Research

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  18. Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumula...

    Authors: Marina M. Ziganshina, Nataliya V. Dolgushina, Galina V. Kulikova, Nafisa M. Fayzullina, Ekaterina L. Yarotskaya, Nailia R. Khasbiullina, Nigora F. Abdurakhmanova, Aleksandra V. Asaturova, Alexander I. Shchegolev, Alina A. Dovgan and Gennady T. Sukhikh

    Citation: Reproductive Biology and Endocrinology 2021 19:73

    Content type: Research

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  19. MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles i...

    Authors: Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Ahmed M. Isa, Hooria Younas, Rachel Ziders, Yousaf Latif Khan, Zahira Hassan, Bilgün Oztürk Turhan, Aysegul Yildiz, Hikmet Hakan Aydin and Ender Yalcinkaya Kalyan

    Citation: Reproductive Biology and Endocrinology 2021 19:72

    Content type: Research

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  20. Proteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversi...

    Authors: Tingting Lei, Ting Qiu, Wanyu Liao, Kangjie Li, Xinyue Lai, Hongbo Huang, Rui Yuan and Ling Chen

    Citation: Reproductive Biology and Endocrinology 2021 19:71

    Content type: Research

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  21. Adenomyosis (ADS) is an estrogen-dependent gynecological disease with unspecified etiopathogenesis. Local hyperestrogenism may serve a key role in contributing to the origin of ADS. Talin1 is mostly identified...

    Authors: Yi-yi Wang, Hua Duan, Sha Wang, Yong-jun Quan, Jun-hua Huang and Zheng-chen Guo

    Citation: Reproductive Biology and Endocrinology 2021 19:70

    Content type: Research

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  22. No information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.

    Authors: Raoul Orvieto, Meirav Noach-Hirsh, Aliza Segev-Zahav, Jigal Haas, Ravit Nahum and Adva Aizer

    Citation: Reproductive Biology and Endocrinology 2021 19:69

    Content type: Research

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  23. Individualization of the follicle-stimulating hormone (FSH) starting dose is considered standard clinical practice during controlled ovarian stimulation (COS) in patients undergoing assisted reproductive techn...

    Authors: Human Fatemi, Wilma Bilger, Deborah Denis, Georg Griesinger, Antonio La Marca, Salvatore Longobardi, Mary Mahony, Xiaoyan Yin and Thomas D’Hooghe

    Citation: Reproductive Biology and Endocrinology 2021 19:68

    Content type: Review

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  24. Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, inc...

    Authors: Maria Simone Oliveira Lima, Benedito Borges da Silva, Menandro Lima de Medeiros, Alesse Ribeiro dos Santos, Emerson Davi do Nascimento Brazil, Walberto Monteiro Neiva Eulálio Filho, Jerusia Oliveira Ibiapina, Antônio Gilberto Albuquerque Brito and Pedro Vitor Lopes Costa

    Citation: Reproductive Biology and Endocrinology 2021 19:67

    Content type: Research

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  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: David B. Seifer, William D. Petok, Alisha Agrawal, Tanya L. Glenn, Arielle H. Bayer, Barry R. Witt, Blair D. Burgin and Harry J. Lieman

    Citation: Reproductive Biology and Endocrinology 2021 19:66

    Content type: Correction

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    The original article was published in Reproductive Biology and Endocrinology 2021 19:28

  26. Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have bee...

    Authors: Junhao Hu, Wenyi Xu, Haiyan Yang and Liangshan Mu

    Citation: Reproductive Biology and Endocrinology 2021 19:65

    Content type: Review

    Published on:

  27. Fluorochloridone (FLC), a selective pyrrolidone herbicide, has been recognized as a potential endocrine disruptor and reported to induce male reproductive toxicity, but the underlying mechanism is unclear. The...

    Authors: Zhijing Ni, Weiqi Sun, Rui Li, Mingjun Yang, Fen Zhang, Xiuli Chang, Weihua Li and Zhijun Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:64

    Content type: Research

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  28. Chemotherapy improves the survival rates of patients with various cancers but often causes some adverse effects, including ovarian damage, characterised by a decrease in primordial follicle stockpiles. Recent ...

    Authors: Jianghui Li, Hui Long, Yanyan Cong, Hongyuan Gao, Qifeng Lyu, Sha Yu and Yanping Kuang

    Citation: Reproductive Biology and Endocrinology 2021 19:63

    Content type: Research

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  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Reza Nejatbakhsh, Maryam Kabir-Salmani, Evdokia Dimitriadis, Ahmad Hosseini, Robabeh Taheripanah, Yousef Sadeghi, Yoshihiro Akimoto and Mitsutoshi Iwashita

    Citation: Reproductive Biology and Endocrinology 2021 19:62

    Content type: Correction

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    The original article was published in Reproductive Biology and Endocrinology 2012 10:46

  30. Poor ovarian response to gonadotropin is a significant challenge in assisted reproductive technique (ART) and affect 9–24% of ART cycles. This study aimed to evaluate the effect of Myo-inositol on fertility ra...

    Authors: Sahar Mohammadi, Fatemeh Eini, Fatemeh Bazarganipour, Seyed Abdolvahab Taghavi and Maryam Azizi Kutenaee

    Citation: Reproductive Biology and Endocrinology 2021 19:61

    Content type: Research

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  31. Low serum progesterone on the day of frozen embryo transfer (FET) is associated with diminished pregnancy rates in artificial endometrium preparation cycles, but there is no consensus on whether strengthened l...

    Authors: Hongyuan Gao, Jing Ye, Hongjuan Ye, Qingqing Hong, Lihua Sun and Qiuju Chen

    Citation: Reproductive Biology and Endocrinology 2021 19:60

    Content type: Research

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  32. Several studies have shown that coenzyme Q10 (CoQ10) can rescue ovarian aging and that ovarian surface epithelium (OSE)-derived ovarian stem cells (OSCs) are useful for treating infertility due to ovarian agin...

    Authors: Hyun Joo Lee, Min Jung Park, Bo Sun Joo, Jong Kil Joo, Yeon Hee Kim, Sun Woo Yang, Chang-Woon Kim and Ki Hyung Kim

    Citation: Reproductive Biology and Endocrinology 2021 19:59

    Content type: Research

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  33. Preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) is widely applied in couples with single reciprocal translocation to increase the chance for a healthy live birth. However, li...

    Authors: Dun Liu, Chuangqi Chen, Xiqian Zhang, Mei Dong, Tianwen He, Yunqiao Dong, Jian Lu, Lihua Yu, Chuanchun Yang and Fenghua Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:58

    Content type: Research

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  34. In mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the accurate chromosome segregation in anaphase. However, we have recently docu...

    Authors: Changyin Zhou, Yilong Miao, Xue Zhang and Bo Xiong

    Citation: Reproductive Biology and Endocrinology 2021 19:57

    Content type: Research

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  35. Hypertension disorder of pregnancy (HDP) is one of the leading causes of maternal and foetal illness. The aim of the current study was to identify and verify novel serum markers for HDP.

    Authors: Shanshui Zeng, Mengru Han, Min Jiang, Fei Liu, Yanwei Hu, Yan Long, Chunyan Zhu, Fangling Zeng, Qiangsheng Gan, Weitao Ye, Wenjin Fu and Hongling Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:56

    Content type: Research

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  36. Thin endometrial thickness (EMT) has been suggested to be associated with reduced incidence of pregnancy rate after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment, but the effect ...

    Authors: Xiaojie Liu, Jingwan Wang, Xiao Fu, Jing Li, Meng Zhang, Junhao Yan, Shanshan Gao and Jinlong Ma

    Citation: Reproductive Biology and Endocrinology 2021 19:55

    Content type: Research

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  37. After ovarian tissue transplantation, ischemia-reperfusion injury and free radicals cause follicle depletion and apoptosis. Therefore, the use of antioxidants to reduce the production of free radicals is an im...

    Authors: Dalin Wang, Menghui Geng, Dongying Gan, Gege Han, Gao Gao, Aying Xing, Yugui Cui and Yanqiu Hu

    Citation: Reproductive Biology and Endocrinology 2021 19:54

    Content type: Research

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  38. To minimize the rate of in vitro fertilization (IVF)- associated multiple-embryo gestation, significant efforts have been made. Previous studies related to machine learning in IVF mainly focused on selecting t...

    Authors: Qingsong Xi, Qiyu Yang, Meng Wang, Bo Huang, Bo Zhang, Zhou Li, Shuai Liu, Liu Yang, Lixia Zhu and Lei Jin

    Citation: Reproductive Biology and Endocrinology 2021 19:53

    Content type: Research

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  39. Live birth has increasingly been identified as the standard clinical approach to measure the success of medically assisted reproduction (MAR). However, previous analyses comparing biosimilar preparations of fo...

    Authors: Su Jen Chua, Ben W. Mol, Salvatore Longobardi, Raoul Orvieto, Christos A. Venetis, Monica Lispi, Ashleigh Storr and Thomas D’Hooghe

    Citation: Reproductive Biology and Endocrinology 2021 19:51

    Content type: Review

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  40. Blood coagulation has been associated with ovulation and female infertility. In this study, the expression of the tissue factor system was examined during ovulation in immature rats; the correlation between ti...

    Authors: You Jee Jang, Hee Kyung Kim, Bum Chae Choi, Sang Jin Song, Jae Il Park, Sang Young Chun and Moon Kyoung Cho

    Citation: Reproductive Biology and Endocrinology 2021 19:52

    Content type: Research

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  41. Anticentromere antibody (ACA) is a member of the antinuclear antibody (ANA) family, and recent studies have found that ACA may be associated with oocyte maturation disorders; however, the possible mechanism be...

    Authors: Ying Ying, Shuang Liu, Yixuan Wu, Sichen Li and Qing Huang

    Citation: Reproductive Biology and Endocrinology 2021 19:50

    Content type: Research

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  43. Proper differentiation of trophoblasts in the human placenta is essential for a successful pregnancy, whereas abnormal regulation of this process may lead to adverse pregnancy outcomes, especially preeclampsia...

    Authors: Wei Peng, Ying Liu, Hongbo Qi and Qingshu Li

    Citation: Reproductive Biology and Endocrinology 2021 19:48

    Content type: Research

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  44. Long-acting, reversible contraceptives (LARC; progestin only) are an increasingly common hormonal contraceptive choice in reproductive aged women looking to suppress ovarian function and menstrual cyclicity. T...

    Authors: Heather C. M. Allaway, Roger A. Pierson, Jesse Invik and Susan A. Bloomfield

    Citation: Reproductive Biology and Endocrinology 2021 19:47

    Content type: Research

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  45. Administration of gonadotropin-releasing hormone agonist (GnRH-a) in the luteal phase is commonly used for pituitary suppression during in vitro fertilisation (IVF). There is an ineluctable risk of inadvertent...

    Authors: Huan Wu, Xiaoyan Xu, Cong Ma, Yiran Zhou, Shanai Pei, Hao Geng, Ye He, Qianhua Xu, Yuping Xu, Xiaojin He, Ping Zhou, Zhaolian Wei, Xiaofeng Xu and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2021 19:46

    Content type: Research

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  46. Some studies have stated that intrauterine insemination (IUI) with controlled ovarian stimulation (COS) might increase the pregnancy rate, while others suggest that IUI in the natural cycle (NC) should be the ...

    Authors: Yan Tang, Qian-Dong He, Ting-Ting Zhang, Jing-Jing Wang, Si-Chong Huang and Yun Ye

    Citation: Reproductive Biology and Endocrinology 2021 19:45

    Content type: Research

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  47. A rapid development in assisted reproductive technology (ART) has led to a surge in its popularity among target couples. However, elucidation on the molecular mechanism and effective solutions for a common pro...

    Authors: Danni Qu, Xiangming Tian, Ling Ding, Yuan Li and Wenhui Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:44

    Content type: Research

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  48. Many infertile couples might experience erectile dysfunction (ED) and significant changes in the quality of sexual life and psychological state though information is limited in secondary infertile men in China...

    Authors: Jianxiong Ma, Yingying Zhang, Binghao Bao, Wangqiang Chen, Haisong Li and Bin Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:43

    Content type: Research

    Published on:

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